![Pharmaceuticals | Free Full-Text | Biased, Bitopic, Opioid–Adrenergic Tethered Compounds May Improve Specificity, Lower Dosage and Enhance Agonist or Antagonist Function with Reduced Risk of Tolerance and Addiction Pharmaceuticals | Free Full-Text | Biased, Bitopic, Opioid–Adrenergic Tethered Compounds May Improve Specificity, Lower Dosage and Enhance Agonist or Antagonist Function with Reduced Risk of Tolerance and Addiction](https://www.mdpi.com/pharmaceuticals/pharmaceuticals-15-00214/article_deploy/html/images/pharmaceuticals-15-00214-g001.png)
Pharmaceuticals | Free Full-Text | Biased, Bitopic, Opioid–Adrenergic Tethered Compounds May Improve Specificity, Lower Dosage and Enhance Agonist or Antagonist Function with Reduced Risk of Tolerance and Addiction
![A novel G protein‐biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein‐coupled receptor kinase - Groom - British Journal of Pharmacology - Wiley Online Library A novel G protein‐biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein‐coupled receptor kinase - Groom - British Journal of Pharmacology - Wiley Online Library](https://bpspubs.onlinelibrary.wiley.com/cms/asset/dcbccccb-1ce8-45e1-b204-b6005d2cd40c/bph15334-toc-0001-m.png)
A novel G protein‐biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein‐coupled receptor kinase - Groom - British Journal of Pharmacology - Wiley Online Library
![Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon - ScienceDirect Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2352345X19301614-fx1.jpg)
Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon - ScienceDirect
![Opioid Hedonic Hotspot in Nucleus Accumbens Shell: Mu, Delta, and Kappa Maps for Enhancement of Sweetness “Liking” and “Wanting” | Journal of Neuroscience Opioid Hedonic Hotspot in Nucleus Accumbens Shell: Mu, Delta, and Kappa Maps for Enhancement of Sweetness “Liking” and “Wanting” | Journal of Neuroscience](https://www.jneurosci.org/content/jneuro/34/12/4239/F3.large.jpg)
Opioid Hedonic Hotspot in Nucleus Accumbens Shell: Mu, Delta, and Kappa Maps for Enhancement of Sweetness “Liking” and “Wanting” | Journal of Neuroscience
![The Impact of Opioid Analgesics and the Pharmacogenomics of ABCB1 in Opioid Dependence and Pharmacotherapies: A Short Review The Impact of Opioid Analgesics and the Pharmacogenomics of ABCB1 in Opioid Dependence and Pharmacotherapies: A Short Review](https://benthamopen.com/contents/figures/TOPAINJ/TOPAINJ-13-7_F1.jpg)
The Impact of Opioid Analgesics and the Pharmacogenomics of ABCB1 in Opioid Dependence and Pharmacotherapies: A Short Review
![Opioid Hedonic Hotspot in Nucleus Accumbens Shell: Mu, Delta, and Kappa Maps for Enhancement of Sweetness “Liking” and “Wanting” | Journal of Neuroscience Opioid Hedonic Hotspot in Nucleus Accumbens Shell: Mu, Delta, and Kappa Maps for Enhancement of Sweetness “Liking” and “Wanting” | Journal of Neuroscience](https://www.jneurosci.org/content/jneuro/34/12/4239/F4.large.jpg)
Opioid Hedonic Hotspot in Nucleus Accumbens Shell: Mu, Delta, and Kappa Maps for Enhancement of Sweetness “Liking” and “Wanting” | Journal of Neuroscience
![Activation of opioid receptors in the enteric nervous system. MOR mu... | Download Scientific Diagram Activation of opioid receptors in the enteric nervous system. MOR mu... | Download Scientific Diagram](https://www.researchgate.net/publication/355537946/figure/fig1/AS:1082947297902592@1635206164135/Activation-of-opioid-receptors-in-the-enteric-nervous-system-MOR-mu-opioid-receptor-DOR.png)
Activation of opioid receptors in the enteric nervous system. MOR mu... | Download Scientific Diagram
![Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience](https://pubs.acs.org/cms/10.1021/acschemneuro.9b00195/asset/images/large/cn-2019-00195v_0008.jpeg)
Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience
![The G protein-first activation mechanism of opioid receptors by Gi protein and agonists | QRB Discovery | Cambridge Core The G protein-first activation mechanism of opioid receptors by Gi protein and agonists | QRB Discovery | Cambridge Core](https://static.cambridge.org/content/id/urn%3Acambridge.org%3Aid%3Aarticle%3AS2633289221000077/resource/name/S2633289221000077_figAb.png?pub-status=live)